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HTP and carbidopa have been reported to improve intention myoclonus (a neuromuscular disorder) in some human cases but not others.

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At very high doses, piribedil has an emetic action on the (CTZ).

Of major concern are reports of a few deaths from liver damage in patients taking the COMT inhibitor tolcapone (Tasmar).

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Exercise therapy in patients with Parkinson disease using a variety of physiotherapy interventions may play a role in improving gait, balance and flexibility, aerobic capacity, initiation of movement, and functional independence.

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There is no evidence that additional benefit will be obtained from the administration of higher doses.

Continuous intrajejunal infusion of levodopa-carbidopa intestinal gel for patients with advanced Parkinson's disease: a randomised, controlled, double-blind, double-dummy study.

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While sleep disturbances can have profound health implications, they may also be quite situation-specific.

Western drugs (mainly l-dopa, dopaminiergic receptor stimulants, and anticholinergics) were used as per usual practice; a control group taking Western drugs alone (24 patients) was also monitored.

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The National Institute of Neurological Disorders and Stroke (NINDS) conducts PD research in laboratories at the National Institutes of Health (NIH) and also supports additional research through grants to major medical institutions across the country.

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Since NO production is important in regulation of blood pressure and blood flow, thereby playing a significant role in cardiovascular diseases, tetrahydrobiopterin is a potential therapeutic target.

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Naturally-oriented physicians may use vitamin B6 for that very reason, to reduce the side effects of these medications.

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The orally disintegrating tablet is not absorbed in the mouth but travels in the saliva to absorption sites in the proximal small bowel (where other levodopa preparations are also absorbed).

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The mental deficits and self-mutilating behavior do not respond well to treatment.

These medications do not stimulate dopamine receptors but affect the movement control center by other means.

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The use of BSM approaches in RLS and PLMD represent not only an under-utilized set of strategies that can be delivered to patients, but also an area with a number of empirical questions to be addressed.

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Families report that affected individuals are more at ease when restrained.

Lithium can cause severe fetal harm and should not be taken during pregnancy, particularly during the first trimester.

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For this reason, prescribers should reassess patients for drowsiness or sleepiness especially since some of the events occur well after the start of treatment.

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LRRK2 mutations are relatively common genetic causes of familial and sporadic PD.

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It appears to reduce spikes in blood glucose in response to a meal up to 8 hours after ingestion in a relatively dose-dependent manner, with descending efficacy.

Do not stop your treatment with Stalevo or Comtan unless told to do so by your healthcare professional.

In patients without motor fluctuations, Carbidopa and Levodopa extended-release, under controlled conditions, provided the same therapeutic benefit with less frequent dosing when compared to Carbidopa and Levodopa.

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Cases of falsely diagnosed pheochromocytoma in patients on carbidopa levodopa therapy have been reported very rarely.

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It is often taken in conjunction with carbidopa to prevent or decrease side effects.

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Bathroom modifications such as handles or grab bars may be needed.

Thus a lack of HGPRT may produce a nucleotide deficiency (specifically: GTP deficiency) disorder, resulting in dopamine deficiency.

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